CHRONIC HEPATITIS OR «DISGUISE» PAROXYSMAL NOCTURAL HEMOGLOBINURIA?
نویسندگان
چکیده
منابع مشابه
Cardiac surgery and paroxysmal noctural hemoglobinuria.
Dear Sir, We read with interest the report by Knobloch et al. on the feasibility of cardiac surgery in a patient with paroxysmal nocturnal hemoglobinuria (PNH). Given the lack of literature in this area we would like to report on another patient with PNH who underwent coronary artery bypass grafting without perioperative complications. Case summary. A 62-year old woman presented in October 2001...
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potent hematopoietic stem cell. In support of this notion, the PNH red cells of women heterozygous for two elec-*Permanent address: Division of Hematology trophoretically distinguishable alleles of the X-linked gene encoding glucose 6-phosphate dehydrogenase Federico II University Medical School Via S Pansini 5 were found all to express the same allele, indicating that they belonged to one clon...
متن کاملParoxysmal nocturnal hemoglobinuria.
Paroxysmal Nocturnal Hemoglobinuria (PNH) literally means to have episodes of hemoglobin in the urine during the night. It is a Coomb's negative rare hemolytic disorder characterized by non-malignant clonal expansion of haemopoietic stem cells due to acquired genetic mutations. A 30 years old male patient presented with 5 years history of transfusion dependent anemia with intermittent episodes ...
متن کاملParoxysmal nocturnal hemoglobinuria.
Keywords Disease name and synonym Definition and Differential Diagnosis Etiology Clinical Description Diagnostic Methods Epidemiology Management References Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder of the bone marrow characterized by the lack (total or partial) of all proteins normally attached to the cell membrane by the glycosylphosphatidylinositol (GPI...
متن کاملParoxysmal nocturnal hemoglobinuria.
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare bone marrow failure disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias. The absence of two glycosylphosphatidylinositol (GPI)-anchored proteins, CD55 and CD59, leads to uncontrolled complement activation that accounts for hemolysis and other PNH manifestations. GPI anchor protein deficiency is almost alw...
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ژورنال
عنوان ژورنال: The Clinician
سال: 2015
ISSN: 1818-8338
DOI: 10.17650/1818-8338-2015-9-2-48-52